Adrenaline (Epinephrine) in Cardiac Arrest
by Marc Colbeck. Last modified: 19/12/14
This is a list of studies addressing the use of Adrenaline/Epinephrine in cardiac arrest. There are many more studies than this. If you know of any, please add them in the comments section and we will include them here.
~MarcAngelos MG1, Butke RL, Panchal AR, Torres CA, Blumberg A, Schneider JE, Aune SE. Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest. Resuscitation. 2008 Apr;77(1):101-10. PMID: 18164797.
Arrich J1, Sterz F, Herkner H, Testori C, Behringer W. Total epinephrine dose during asystole and pulseless electrical activity cardiac arrests is associated with unfavourable functional outcome and increased in-hospital mortality. Resuscitation. 2012 Mar;83(3):333-7. PMID: 22079948.
Biondi-Zoccai GG1, Abbate A, Parisi Q, Agostoni P, Burzotta F, Sandroni C, Zardini P, Biasucci LM. Is vasopressin superior to adrenaline or placebo in the management of cardiac arrest? A meta-analysis. Resuscitation. 2003 Nov;59(2):221-4. PMID: 14625113.
Burnett AM1, Segal N, Salzman JG, McKnite MS, Frascone RJ. Potential negative effects of epinephrine on carotid blood flow and ETCO2 during active compression-decompression CPR utilizing an impedance threshold device. Resuscitation. 2012 Aug;83(8):1021-4. PMID: 22445865.
Dumas F1, Bougouin W2, Geri G2, Lamhaut L3, Bougle A4, Daviaud F4, Morichau-Beauchant T4, Rosencher J5, Marijon E6, Carli P7, Jouven X6, Rea TD8, Cariou A2. Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? J Am Coll Cardiol. 2014 Dec 9;64(22):2360-7. PMID: 25465423.
Fothergill RT1, Watson LR, Chamberlain D, Virdi GK, Moore FP, Whitbread M. Increases in survival from out-of-hospital cardiac arrest: a five year study. Resuscitation. 2013 Aug;84(8):1089-92. PMID: 23583613.
Hagihara A1, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012 Mar 21;307(11):1161-8. PMID: 22436956.
Herlitz J1, Ekström L, Wennerblom B, Axelsson A, Bång A, Holmberg S. Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference? Resuscitation. 1995 Jun;29(3):195-201. PMID: 7667549.
Jacobs IG1, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial. Resuscitation. 2011 Sep;82(9):1138-43. PMID: 21745533.
Jeung KW1, Ryu HH, Song KH, Lee BK, Lee HY, Heo T, Min YI. Variable effects of high-dose adrenaline relative to standard-dose adrenaline on resuscitation outcomes according to cardiac arrest duration. Resuscitation. 2011 Jul;82(7):932-6. PMID: 21482013.
Koscik C1, Pinawin A, McGovern H, Allen D, Media DE, Ferguson T, Hopkins W, Sawyer KN, Boura J, Swor R. Rapid epinephrine administration improves early outcomes in out-of-hospital cardiac arrest. Resuscitation. 2013 Jul;84(7):915-20. PMID: 23523823.
Lin S1, Callaway CW2, Shah PS3, Wagner JD4, Beyene J5, Ziegler CP6, Morrison LJ7. Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials. Resuscitation. 2014 Jun;85(6):732-40. PMID: 24642404.
Miller C1. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: the use of adrenaline and long-term survival in cardiopulmonary resuscitation following cardiac arrest. Emerg Med J. 2013 Mar;30(3):249-50. PMID: 23413305.
Nordseth T1, Olasveengen TM, Kvaløy JT, Wik L, Steen PA, Skogvoll E. Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA). Resuscitation. 2012 Aug;83(8):946-52. PMID: 22429969.
Ohshige K1, Shimazaki S, Hirasawa H, Nakamura M, Kin H, Fujii C, Okuchi K, Yamamoto Y, Akashi K, Takeda J, Hanyuda T, Tochikubo O. Evaluation of out-of-hospital cardiopulmonary resuscitation with resuscitative drugs: a prospective comparative study in Japan. Resuscitation. 2005 Jul;66(1):53-61. PMID: 15993730.
Olasveengen TM1, Wik L, Sunde K, Steen PA. Outcome when adrenaline (epinephrine) was actually given vs. not given - post hoc analysis of a randomized clinical trial. Resuscitation. 2012 Mar;83(3):327-32. PMID: 22115931.
Ong ME1, Tan EH, Ng FS, Panchalingham A, Lim SH, Manning PG, Ong VY, Lim SH, Yap S, Tham LP, Ng KS, Venkataraman A; Cardiac Arrest and Resuscitation Epidemiology Study Group. Survival outcomes with the introduction of intravenous epinephrine in the management of out-of-hospital cardiac arrest. Ann Emerg Med. 2007 Dec;50(6):635-42. PMID: 17509730.
Ong ME1, Tiah L, Leong BS, Tan EC, Ong VY, Tan EA, Poh BY, Pek PP, Chen Y. A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department. Resuscitation. 2012 Aug;83(8):953-60. PMID: 22353644.
Raffay V1, Chalkias A2, Lelovas P3, Karlis G3, Koutsovasilis A3, Papalois A4, Jevdjic J5, Fiser Z1, Xanthos T3. Addition of glucagon to adrenaline improves hemodynamics in a porcine model of prolonged ventricular fibrillation. Am J Emerg Med. 2014 Feb;32(2):139-43. PMID: 24238484.
Warren SA1, Huszti E2, Bradley SM3, Chan PS4, Bryson CL3, Fitzpatrick AL5, Nichol G6; American Heart Association's Get With the Guidelines-Resuscitation (National Registry of CPR) Investigators. Adrenaline (epinephrine) dosing period and survival after in-hospital cardiac arrest: a retrospective review of prospectively collected data. Resuscitation. 2014 Mar;85(3):350-8. PMID: 24252225.
Woodhouse SP1, Cox S, Boyd P, Case C, Weber M. High dose and standard dose adrenaline do not alter survival, compared with placebo, in cardiac arrest. Resuscitation. 1995 Dec;30(3):243-9. PMID: 8867714.
Xanthos T1, Pantazopoulos I, Demestiha T, Stroumpoulis K. Epinephrine in ventricular fibrillation: friend or foe? A review for the Emergency Nurse. J Emerg Nurs. 2011 Jul;37(4):408-12; quiz 425-6. PMID: 21741574.
The following two tabs change content below.Senior Lecturer at Australian Catholic UniversityMarc is a Canadian Critical Care Paramedic with 14 years of clinical experience who has been working as a professional educator since the early 2000's. He has taught at the College and University level in the Middle East and Australia, and worked as the General Manager of Clinical Governance for an Australian State Ambulance Service. He is currently a Senior Lecturer at Australian Catholic University in Queensland, Australia. His undergraduate degree is in PreHospital Care and his MA is in Counseling Psychology. He is currently working on a PhD in Translational Health Sciences with the Joanna Briggs Institute at the University of Adelaide, with a special interest in the development and maintenance of paramedic CPGs. His website is www.marccolbeck.info.
Latest posts by Marc Colbeck (see all)
- Developing effective clinical practice guidelines for ambulance services. - 04/04/15
- Adherence to guidelines and protocols in the prehospital and emergency care setting: a systematic review. - 07/03/15
- Knowledge translation in emergency medical services: A qualitative survey of barriers to guideline implementation. - 26/02/15
- Adherence to resuscitation guidelines during prehospital care of cardiac arrest patients - 14/01/15
- Adherence to guidelines and protocols in the prehospital and emergency care setting: a systematic review - 05/01/15
Adrenaline (Epinephrine) in Cardiac Arrest
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